Title of article
Transcriptional and epigenetic regulation of human microRNAs
Author/Authors
Wang، نويسنده , , Zifeng and Yao، نويسنده , , Hong and Lin، نويسنده , , Sheng and Zhu، نويسنده , , Xiao and Shen، نويسنده , , Zan and Lu، نويسنده , , Gang and Poon، نويسنده , , Wai Sang and Xie، نويسنده , , Dan and Lin، نويسنده , , Marie Chia-mi and Kung، نويسنده , , Hsiang-fu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
10
From page
1
To page
10
Abstract
MicroRNAs (miRNAs) are members of non-coding RNAs. They are involved in diverse biological functions. MiRNAs are precisely regulated in a tissue- and developmental-specific manner, but dysregulated in many human diseases, in particular cancers. Transcriptional regulation, post-transcriptional regulation, as well as genetic alterations, are the three major mechanisms controlling the spatial and temporal expression of miRNAs. Emerging evidence now indicates that transcriptional and epigenetic regulations play major roles in miRNA expression. This review summarizes the current knowledge and discusses the future challenges.
Keywords
Transcription machinery , Transcriptional regulation , CANCER , epigenetic regulation , miRNA
Journal title
Cancer Letters
Serial Year
2013
Journal title
Cancer Letters
Record number
1822434
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