Author/Authors :
Berger، نويسنده , , Elisa and Soldati، نويسنده , , Rocio and Huebener، نويسنده , , Nicole and Hohn، نويسنده , , Oliver and Stermann، نويسنده , , Alexander and Durmus، نويسنده , , Tahir and Lobitz، نويسنده , , Stephan and Zenclussen، نويسنده , , Ana C. and Christiansen، نويسنده , , Holger and Lode، نويسنده , , Holger N. and Fest، نويسنده , , Stefan، نويسنده ,
Abstract :
Attenuated Salmonella is an approved oral life vaccine that is currently entering pre-clinical cancer vaccination studies as a promising DNA carrier. In a syngeneic mouse model for neuroblastoma, oral gavage of Salmonella typhimurium (SL7207) carrying recent generated survivin DNA vaccines induced a stronger cellular anti-NB immune response than gene gun application or injection of lentivirally transduced bone marrow-derived DCs. The level of Salmonella-associated side effects was not significant as indicated by unaffected survivin-mediated hematopoiesis and wound healing. We believe that our findings provide an important baseline to translate Salmonella-based DNA vaccination into a clinical application for neuroblastoma.
Keywords :
Neuroblastoma , SL7207 , dendritic cells , Gene gun , lentiviral particle
