Author/Authors :
Nishi، نويسنده , , Tetsuo and Iwasaki، نويسنده , , Kenta and Ohashi، نويسنده , , Norifumi and Tanaka، نويسنده , , Chie and Kobayashi، نويسنده , , Daisuke and Nakayama، نويسنده , , Goro and Koike، نويسنده , , Masahiko and Fujiwara، نويسنده , , Michitaka and Kobayashi، نويسنده , , Takaaki and Kodera، نويسنده , , Yasuhiro، نويسنده ,
Abstract :
We studied the effect of everolimus, an inhibitor of the mammalian target of rapamycin (mTOR) on human gastric cancer cell lines. Cell proliferation in 3 of 8 cell lines was effectively inhibited by everolimus. Basal phosphorylation level of 4E-BP1 (T37/46, T70) was significantly higher in everolimus-sensitive cells than in everolimus-resistant cells. In subcutaneous xenograft model, immunohistochemistry analysis revealed that everolimus-sensitive cells expressed high levels of phospho-4E-BP1 (T37/46). In conclusion, phosphorylation of 4E-BP1 may be a predictive biomarker of everolimus sensitivity in gastric cancer.
Keywords :
mTOR inhibitor , Sensitivity , Erk , Gastric cancer , 4E-BP1
