Author/Authors :
Bougen، نويسنده , , N.M. and Amiry، نويسنده , , N. and Yuan، نويسنده , , Y. and Kong، نويسنده , , X.J. and Pandey، نويسنده , , V. and Vidal، نويسنده , , L.J.P. and Perry، نويسنده , , J.K. and Zhu، نويسنده , , T. and Lobie، نويسنده , , P.E.، نويسنده ,
Abstract :
Metastasis is the primary mediator of prostate cancer (PCA) lethality and poses a significant clinical obstacle. The identification of factors involved in the metastasis of PCA is imperative. We demonstrate herein that trefoil factor 1 (TFF1) promotes PCA cell migration and invasion in vitro and metastasis in vivo. The capacity of TFF1 to enhance cell migration/invasion is mediated by transcriptional repression of E-CADHERIN. Consideration of targeted inhibition of TFF1 to prevent metastasis of prostate carcinoma is warranted.
Keywords :
prostate cancer , Trefoil factor 1 , Epithelial-to-mesenchymal transition , metastasis
