Author/Authors :
Zhang، نويسنده , , Lin and Liu، نويسنده , , Xiaodong and Jin، نويسنده , , Haifeng and Guo، نويسنده , , Xuegang and Xia، نويسنده , , Limin and Chen، نويسنده , , Zhangqian and Bai، نويسنده , , Ming and Liu، نويسنده , , Jian Ku Shang، نويسنده , , Xin and Wu، نويسنده , , Kaichun and Pan، نويسنده , , Yanglin and Fan، نويسنده , , Daiming، نويسنده ,
Abstract :
In this study, we detected miR-206 expression in gastric cancer (GC) and further investigated its effects on GC cell growth in vitro and in vivo. MiR-206 expression was found to be significantly decreased in 30 GC samples and GC cell lines by Real time-PCR. Restoration of miR-206 reduced cell growth and colony forming ability in GC cells with G0/G1 cell cycle arrest. Further studies demonstrated that miR-206 could suppress GC cells proliferation at least partially through targeting the CyclinD2 (CCND2). Therefore, we provided evidence that miR-206 was a potential tumor suppressor and may be used as a therapeutic target for gastric cancer.
Keywords :
Proliferation , MiR-206 , CyclinD2 , Gastric cancer
