Title of article :
Acute Monocytic Leukemia with a Novel 10;11 Rearrangement Resolved by Fluorescence In Situ Hybridization
Author/Authors :
Sinclair، نويسنده , , Elizabeth J and Jalihal، نويسنده , , Sanjeev and Watmore، نويسنده , , Ann E، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
Fluorescence in situ hybridization analysis in an adult with acute monocytic leukemia revealed the complex nature of a rearrangement between chromosomes 10 and 11, which resulted in disruption of the MLL gene. Using a combination of chromosome 10 and 11 paints, a 10 centromere-specific sequence, and a probe for the MLL locus at 11q23, the rearrangement was deduced to have involved a reciprocal translocation between chromosomes 10 and 11, followed by an inversion within the short arm of the derivative 10. To our knowledge, this novel rearrangement has not been described previously.
Journal title :
Cancer Genetics and Cytogenetics
Journal title :
Cancer Genetics and Cytogenetics