Author/Authors :
Lounnas، نويسنده , , Nadia and Rosilio، نويسنده , , Célia and Nebout، نويسنده , , Marielle and Mary، نويسنده , , Didier and Griessinger، نويسنده , , Emmanuel and Neffati، نويسنده , , Zouhour and Chiche، نويسنده , , Johanna and Spits، نويسنده , , Hergen and Hagenbeek، نويسنده , , Thijs J. and Asnafi، نويسنده , , Vahid and Poulsen، نويسنده , , Sally-Ann and Supuran، نويسنده , , Claudiu T. and Peyron، نويسنده , , Jean-François and Imbert، نويسنده , , Véronique، نويسنده ,
Abstract :
The membrane-bound carbonic anhydrase isoforms CAIX and CAXII, underpin a pH-regulating system that enables hypoxic tumor cell survival. Here, we observed for the first time an upregulation of CAXII in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LL) cells. First we showed that CAXII is overexpressed in thymocytes from tPTEN−/− mice suffering of T lymphoma and that its pharmacological inhibition decreased cell proliferation and induced apoptosis. The same results were observed with the SupT1 human T cell lymphoma line. In addition we observed an upregulation of CAXII in human T-ALL samples supporting the case that CAXII may represent a new therapeutic target for T-ALL/LL.
