Author/Authors :
Fujishima، نويسنده , , Masumi and Takahashi، نويسنده , , Naoto and Miura، نويسنده , , Ikuo and Kobayashi، نويسنده , , Yoshimi and Kume، نويسنده , , Masaaki and Nishinari، نويسنده , , Tamio and Miura، نويسنده , , Akira B، نويسنده ,
Abstract :
We describe a patient with acute promyelocytic leukemia (APL) carrying a new complex variant translocation of t(2;15;17)(q21;q22;q21). The karyotypic interpretation was confirmed by fluorescence in situ hybridization (FISH) with the use of painting probes of chromosomes 2, 15, and 17 and a PML/RARA dual color DNA probe. FISH showed a PML/RARA fusion gene on the der(2) instead of the der(15). These results suggest that the critical event in the development of APL is the formation of a PML/RARA chimeric gene, regardless of its locus in the genome.
