Simultaneous Presence of t(2;8)(p12;q24) and t(14;18)(q32;q21) in a B-Cell Lymphoproliferative Disorder with Features Suggestive of an Aggressive Variant of Splenic Marginal-zone Lymphoma

We report a case of an aggressive variant of splenic marginal-zone lymphona (SMZL) with circulating villous lymphocytes. The karyotype of all examined cells had multiple structural and numerical abnormalities, including two lymphoma characteristic translocations, t(2;8)(p12;q24) and t(14;18)(q32;q21). Based on a literature review of cytogenetic aberrations of splenic lymphoma with villous lymphocytes (SLVL) and SMZL, this is apparently the first documentation of these two translocations in a case of SMZL, and could reflect the heterogeneity of the disorder.