Title of article
Cytogenetic and Fluorescence In Situ Hybridization Studies in Four Cases of Plasma Cell Leukemia
Author/Authors
Lloveras، نويسنده , , Elisabet and Solé، نويسنده , , Francesc and Espinet، نويسنده , , Blanca and Besses، نويسنده , , Carles and Asensio، نويسنده , , Antoni and Abella، نويسنده , , Eugènia and Woessner، نويسنده , , Soledad and Florensa، نويسنده , , Lourdes، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
163
To page
166
Abstract
We present a cytogenetic and fluorescence in situ hybridization (FISH) study, using centromeric probes for chromosomes 3, 7, 11, and 18, TP53 gene (17p13), and RB-1 locus (13q14) DNA probes, in four cases of plasma cell leukemia (PCL). Among the four cases, three presented monosomy of the RB-1 locus and one monoallelic deletion of the TP53 gene. The present report shows the usefulness of the FISH technique to detect abnormalities not previously observed by conventional cytogenetics.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
2000
Journal title
Cancer Genetics and Cytogenetics
Record number
1823055
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