Title of article :
Prediction of response to neoadjuvant chemotherapy in breast cancer patients by circulating apoptotic biomarkers nucleosomes, DNAse, cytokeratin-18 fragments and survivin
Author/Authors :
Stoetzer، نويسنده , , Oliver J. and Fersching، نويسنده , , Debora M.I. and Salat، نويسنده , , Christoph and Steinkohl، نويسنده , , Oliver and Gabka، نويسنده , , Christian J. and Hamann، نويسنده , , Ulrich and Braun، نويسنده , , Michael and Feller، نويسنده , , Axel-Mario and Heinemann، نويسنده , , Volker and Siegele، نويسنده , , Barbara and Nagel، نويسنده , , Dorothea and Holdenrieder، نويسنده , , Stefan، نويسنده ,
Abstract :
Biomarkers predicting response to neoadjuvant chemotherapy in locally confined breast cancer (LBC) are highly needed. We prospectively assessed serial blood levels of apoptotic biomarkers nucleosomes, DNAse activity, cytokeratin-18 fragments (M30) and survivin in 51 LBC patients and correlated them with response to neoadjuvant treatment and established tumor markers. As controls, we used 31 healthy subjects, 13 patients with benign diseases and 28 with metastatic breast cancer (MBC). Levels of nucleosomes and survivin were elevated in LBC and MBC while M30, CEA and CA 15-3 levels were only elevated in MBC. During neoadjuvant chemotherapy, LBC patients with no change of disease (N = 13) had significantly higher pretherapeutic levels of nucleosomes than patients with remission (N = 38). We conclude that apoptotic biomarkers bear valuable information for diagnosis and therapy response prediction in LBC patients.
Keywords :
breast cancer , Cytokeratin fragments , nucleosomes , Survivin , Neoadjuvant chemotherapy , Apoptotic biomarkers
