Author/Authors :
Bonomi، نويسنده , , Rossana and Giordano، نويسنده , , Hugo and del Pilar Moreno، نويسنده , , Mar??a and Bodega، نويسنده , , Enrique and Landoni، نويسنده , , Ana Inés and Gallagher، نويسنده , , Robert and del Rosario Uriarte، نويسنده , , Mar??a، نويسنده ,
Abstract :
We report a patient with acute promyelocytic leukemia with the common translocation (15;17) and PML-RARAα fusion gene. In relapse, blasts showed typical FAB M2 morphologic features, and the karyotype was 45,X, −Y,t(8;21). A reexamination of the leukemic cells at diagnosis revealed that an AML1-ETO fusion gene was also present at that time without cytogenetic evidence of t(8;21). In relapse, only t(8;21) was detected. Two different clones were identified by cytogenetic standard techniques. The association of two common translocations supervening in the same time in the same cells could not be established.
