Title of article :
Antitumoral effects of vasoactive intestinal peptide in human renal cell carcinoma xenografts in athymic nude mice
Author/Authors :
Vacas، نويسنده , , Eva and Arenas، نويسنده , , M. Isabel and Muٌoz-Moreno، نويسنده , , Laura and Bajo، نويسنده , , Ana M. and Sلnchez-Chapado، نويسنده , , Manuel Hermida-Prieto، نويسنده , , Juan C. and Carmena، نويسنده , , Marيa J.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Abstract :
We studied antitumor effect of VIP in human renal cell carcinoma (RCC) (A498 cells xenografted in immunosuppressed mice). VIP-treated cells gave resulted in p53 upregulation and decreased nuclear β-catenin translocation and NFκB expression, MMP-2 and MMP-9 activities, VEGF levels and CD-34 expression. VIP led to a more differentiated tubular organization in tumours and less metastatic areas. Thus, VIP inhibits growth of A498-cell tumours acting on the major issues involved in RCC progression such as cell proliferation, microenvironment remodelling, tumour invasion, angiogenesis and metastatic ability. These antitumoral effects of VIP offer new therapeutical possibilities in RCC treatment.
Keywords :
VIP , MMP , VEGF , ccRCC , NF?B
Journal title :
Cancer Letters
Journal title :
Cancer Letters
