Title of article
P97/CDC-48: Proteostasis control in tumor cell biology
Author/Authors
Fessart، نويسنده , , Delphine and Marza، نويسنده , , Esther and Taouji، نويسنده , , Saïd and Delom، نويسنده , , Frédéric and Chevet، نويسنده , , Eric، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
9
From page
26
To page
34
Abstract
P97/CDC-48 is a prominent member of a highly evolutionary conserved Walker cassette – containing AAA + ATPases. It has been involved in numerous cellular processes ranging from the control of protein homeostasis to membrane trafficking through the intervention of specific accessory proteins. Expression of p97/CDC-48 in cancers has been correlated with tumor aggressiveness and prognosis, however the precise underlying molecular mechanisms remain to be characterized. Moreover p97/CDC-48 inhibitors were developed and are currently under intense investigation as anticancer drugs. Herein, we discuss the role of p97/CDC-48 in cancer development and its therapeutic potential in tumor cell biology.
Keywords
proteostasis , cancer , p97 , VCP , CDC-48
Journal title
Cancer Letters
Serial Year
2013
Journal title
Cancer Letters
Record number
1823343
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