Author/Authors :
Wu، نويسنده , , Shuai and Lao، نويسنده , , Xinyuan and Sun، نويسنده , , Tian-Tian and Ren، نويسنده , , Lin-Lin and Kong، نويسنده , , Xuan and Wang، نويسنده , , Jilin and Wang، نويسنده , , Ying-Chao and Du، نويسنده , , Wan and Yu، نويسنده , , Ya-Nan and Weng، نويسنده , , Yu-Rong and Hong، نويسنده , , Jie and Fang، نويسنده , , Jing-Yuan، نويسنده ,
Abstract :
Zinc finger protein X-linked (ZFX) is a zinc finger transcription factor encoded on the X chromosome. Here, we found that ZFX expression was significantly upregulated in gastric cancer (GC) cell lines and tissues. Knockdown of ZFX induced significant apoptosis and cell cycle arrest in SGC7901 and MGC803 cells. Moreover, we demonstrated for the first time that knockdown of ZFX inhibited gastric cancer cell growth in vitro and in vivo via downregulating the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK-MAPK) pathway. Therefore, ZFX play a prominent role in GC tumorigenicity and may have potential applications in the diagnosis or treatment of GC.
