Comparative genomic hybridization analysis of transitional cell carcinomas of the renal pelvis

We used comparative genomic hybridization to analyze 10 primary tumor samples from patients with transitional cell carcinoma of the renal pelvis. The most frequent loss was located at 9q, that is, in 50% of the tumors. Gains of DNA sequences were most frequently observed in chromosome regions 1q21∼q23, 2p23∼p25, 8q21.1∼q22 and in the whole chromosome 20. High level amplifications at 1q21∼q25, 6p22∼p23, 8q21∼q22, 8q22∼q24.1, 11q13, and 12q14∼q21 were detected. Most of these regions have previously been reported to be involved in transitional cell carcinoma of the bladder, thus confirming the importance of an increasing number of chromosome imbalances in the development and progression of this type of tumors.