Author/Authors :
Wu، نويسنده , , Xi and Peng، نويسنده , , Meiyu and Huang، نويسنده , , Bingqing and Zhang، نويسنده , , Huan and Wang، نويسنده , , Huafeng and Huang، نويسنده , , Biao and Xue، نويسنده , , Zhenyi and Zhang، نويسنده , , Lijuan and Da، نويسنده , , Yurong and Yang، نويسنده , , De-Yong Yao، نويسنده , , Zhi and Zhang، نويسنده , , Rongxin، نويسنده ,
Abstract :
Cancer immunoediting consists of three distinct phases: elimination, equilibrium and escape. Here, for the first time, we investigated the immune microenvironment profiles of tumor immune equilibrium and immune escape states in 3′-methylcholanthrene-induced murine sarcoma model. Our study indicates the relative balance of monocytic MDSCs and antitumor immunity cells (especially CTLs, NK cells and γδT cells) may involve in maintaining tumor cells in a state of immune-mediated dormancy. In addition, high percentages of Treg cells and PMN-MDSCs are associated with the tumor immune escape state – mice with progressing sarcomas. In summary, the relative balance of immune effector cells and suppressive populations in the tumor microenvironment may involve in determining the fate of tumors.
Keywords :
Immunoediting , Immune microenvironment , Immune escape , Dormant sarcomas , Immune equilibrium
