Author/Authors :
Kim، نويسنده , , Sun-Hee and Wang، نويسنده , , Dingzhi and Park، نويسنده , , Yun-Yong and Katoh، نويسنده , , Hiroshi and Margalit، نويسنده , , Ofer and Sheffer، نويسنده , , Michal and Wu، نويسنده , , Hong and Holla، نويسنده , , Vijaykumar R. and Lee، نويسنده , , Ju-Seog and DuBois، نويسنده , , Raymond N.، نويسنده ,
Abstract :
HIG2 (hypoxia-inducible gene 2) is a biomarker of hypoxia and elevated in several cancers. Here, we show that HIG2 also upregulated HIF-1α expression under hypoxic conditions and enhanced AP-1 expression under normoxic conditions, which affects colorectal cancer cell survival. Importantly, over-expression of HIG2 promoted tumor growth by suppressing apoptosis in a mouse orthotopic model. These results are likely relevant to human disease since we found that the expression of HIG2 is gradually elevated as tumors progress. Collectively, these findings suggest that HIG2 plays an important role in promoting colorectal cancer growth in hypoxia-dependent and independent manners.
Keywords :
Survival , Hypoxia , normoxia , HIG2 , HIF-1? , Colorectal Cancer
