• Title of article

    miR-15a inhibits cell proliferation and epithelial to mesenchymal transition in pancreatic ductal adenocarcinoma by down-regulating Bmi-1 expression

  • Author/Authors

    Guo، نويسنده , , Shixiang and Xu، نويسنده , , Xuejun and Tang، نويسنده , , Yichen and Zhang، نويسنده , , Chaobin and Li، نويسنده , , Jian-Ming Ouyang، نويسنده , , Yongsheng and Ju، نويسنده , , Jingfang and Bie، نويسنده , , Ping and Wang، نويسنده , , Huaizhi، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2014
  • Pages
    7
  • From page
    40
  • To page
    46
  • Abstract
    AbstractPurposes estigate whether miR-15a inhibits cell proliferation and epithelial–mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) via the down-regulation of B cell-specific moloney murine leukemia virus insertion site 1 (Bmi-1) expression. s and Results a and Bmi-1 expressions in normal pancreatic tissue and PDAC tissue were measured. The relationship between miR-15a and Bmi-1 expression was analyzed. We found that miR-15a suppressed the expression of Bmi-1 and PDAC cell proliferation; E-cadherin expression was visibly up-regulated after silencing Bmi-1 by transfecting miR-15a into PDAC cell line. sion a inhibits cell proliferation and EMT in PDAC via the down-regulation of Bmi-1 expression.
  • Keywords
    Bmi-1 , EMT , miR-15a , Proliferation , Pancreatic ductal adenocarcinoma
  • Journal title
    Cancer Letters
  • Serial Year
    2014
  • Journal title
    Cancer Letters
  • Record number

    1824172

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1824172