Author/Authors :
Shigdar، نويسنده , , Sarah and Li، نويسنده , , Yong and Bhattacharya، نويسنده , , Santanu and O’Connor، نويسنده , , Michael and Pu، نويسنده , , Chunwen and Lin، نويسنده , , Jia and Wang، نويسنده , , Tao and Xiang، نويسنده , , Dongxi and Kong، نويسنده , , Lingxue and Wei، نويسنده , , Ming Q. and Zhu، نويسنده , , Yimin and Zhou، نويسنده , , Shufeng and Duan، نويسنده , , Wei، نويسنده ,
Abstract :
Cancer stem cells are becoming recognised as being responsible for metastasis and treatment resistance. The complex cellular and molecular network that regulates cancer stem cells and the role that inflammation plays in cancer progression are slowly being elucidated. Cytokines, secreted by tumour associated immune cells, activate the necessary pathways required by cancer stem cells to facilitate cancer stem cells progressing through the epithelial–mesenchymal transition and migrating to distant sites. Once in situ, these cancer stem cells can secrete their own attractants, thus providing an environment whereby these cells can continue to propagate the tumour in a secondary niche.
Keywords :
Microenvironment , Epigenetics , Epithelial–mesenchymal transition , Cancer stem cells , inflammation
