Title of article
MUC1 drives epithelial–mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter
Author/Authors
Marco Gnemmi، نويسنده , , Viviane and Bouillez، نويسنده , , Audrey and Gaudelot، نويسنده , , Kelly and Hémon، نويسنده , , Brigitte and Ringot، نويسنده , , Bélinda and Pottier، نويسنده , , Nicolas and Glowacki، نويسنده , , François and Villers، نويسنده , , Arnauld and Vindrieux، نويسنده , , David and Cauffiez، نويسنده , , Christelle and Seuningen، نويسنده , , Isabelle Van and Bernard، نويسنده , , David and Leroy، نويسنده , , Xavier L. Aubert، نويسنده , , Sébastien and Perrais، نويسنده , , Michaël، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
12
From page
225
To page
236
Abstract
MUC1 is overexpressed in human carcinomas. The transcription factor SNAIL can activate epithelial–mesenchymal transition (EMT) in cancer cells. In this study, in renal carcinoma, we demonstrate that (i) MUC1 and SNAIL were overexpressed in human sarcomatoid carcinomas, (ii) SNAIL increased indirectly MUC1 expression, (iii) MUC1 overexpression induced EMT, (iv) MUC1 C-terminal domain (MUC1-C) and β-catenin increased SNAIL transcriptional activity by interaction with its promoter and (v) blocking MUC1-C nuclear localization decreased Wnt/β-catenin signaling pathway activation and SNAIL expression. Altogether, our findings demonstrate that MUC1 is an actor in EMT and appears as a new therapeutic target.
Keywords
Beta catenin , GO-203 , Snail , MUC1 , Epithelial mesenchymal transition
Journal title
Cancer Letters
Serial Year
2014
Journal title
Cancer Letters
Record number
1824484
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