Title of article :
Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways
Author/Authors :
Zhao، نويسنده , , Baolei and Ma، نويسنده , , Yong and Xu، نويسنده , , Zhilin and Wang، نويسنده , , Jizhou and Wang، نويسنده , , Fengjun and Wang، نويسنده , , Dawei and Pan، نويسنده , , Shangha and Wu، نويسنده , , Yaohua and Pan، نويسنده , , Huayang and Xu، نويسنده , , Dongsheng and Liu، نويسنده , , Lianxin and Jiang، نويسنده , , Hongchi، نويسنده ,
Abstract :
The present study aimed to investigate the anti-cancer effects of hydroxytyrosol (HT) in human hepatocellular carcinoma (HCC) cells. Our results show that HT could inhibit proliferation, induce G2/M cell cycle arrest and apoptosis in human HCC cells. Mechanically, we found that HT could suppress the activation of AKT and nuclear factor-kappa B (NF-κB) pathways. HT also significantly inhibited the tumor growth, angiogenesis and the activation of AKT and NF-κB pathways in an orthotopic model of human HCC in vivo. These data suggest that HT may be a promising candidate agent for the treatment of HCC.
Keywords :
Hydroxytyrosol , hepatocellular carcinoma , Akt , Nuclear factor-?B , mice
