Author/Authors :
Liu، نويسنده , , Jingjing and Wang، نويسنده , , Xu and Yang، نويسنده , , Xiaoning and Liu، نويسنده , , Yunpeng and Shi، نويسنده , , Ying and Ren، نويسنده , , Jianlin and Guleng، نويسنده , , Bayasi and Ren، نويسنده ,
Abstract :
TFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3′UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer.
Keywords :
Gastric cancer , miR-423-5p , Trefoil factor 1 (TFF1) , Proliferation and invasion , Expression regulation
