Author/Authors :
Andrieux، نويسنده , , Joris and Demory، نويسنده , , Jean Loup and Morel، نويسنده , , Pierre and Plantier، نويسنده , , Isabelle and Dupriez، نويسنده , , Brigitte and Caulier، نويسنده , , Marie Thérèse and Bauters، نويسنده , , Francis and La??، نويسنده , , Jean Luc، نويسنده ,
Abstract :
Among cytogenetic studies of 205 patients diagnosed as myelofibrosis with myeloid metaplasia, we found seven cases with structural abnormalities of the long arm of chromosome 12. The karyotype showed six balanced translocations, that is, t(4;12)(q33;q21), t(5;12)(p14;q21), t(1;12)(q22;q24), t(12;17)(q24;q11), t(7;12) (p11;q24), and t(1;12)(p12;q24), as well as other cytogenetic abnormalities such as del(12)(q21;q24) and inv(12) (p12q24). Some isolated cases involving the 12q21 region have also been described in the literature. Importance of rearrangement of chromosome 12 in 12q21 or 12q24 is underlined by the authors suggesting a proto-oncogene accountable mechanism of leukemogenesis.
