Author/Authors :
Morel، نويسنده , , Frédéric and Herry، نويسنده , , Angèle and Le Bris، نويسنده , , Marie-Josée and Douet-Guilbert، نويسنده , , Nathalie and Le Calvez، نويسنده , , Geneviève and Marion، نويسنده , , Véronique and Berthou، نويسنده , , Christian and De Braekeeler، نويسنده , , Marc، نويسنده ,
Abstract :
We report an 8-year-old girl with B-cell acute lymphoblastic leukemia (ALL). The blast cell karyotype at diagnosis included a marker chromosome revealed by fluorescence in situ hybridization to be a derivative of chromosome 21. A high level amplification of the AML1 gene was identified, but it disappeared upon complete remission. This rare but recurrent abnormality warrants research of B-cell ALL, especially when a marker chromosome is present in the blast cell karyotype.
