Title of article :
MicroRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer
Author/Authors :
Tsai، نويسنده , , Ming-Ming and Wang، نويسنده , , Chia-Siu and Tsai، نويسنده , , Chung-Ying and Chen، نويسنده , , Cheng-Yi and Chi، نويسنده , , Hsiang-Cheng and Tseng، نويسنده , , Yi-Hsin and Chung، نويسنده , , Pei-Jung and Lin، نويسنده , , Yang-Hsiang and Chung، نويسنده , , I-Hsiao and Chen، نويسنده , , Ching-Ying and Lin، نويسنده , , Kwang-Huei، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Pages :
10
From page :
222
To page :
231
Abstract :
MicroRNAs (miRNAs) play an important role to contribute carcinogenesis. The aim of the current study was to identify useful biomarkers from miRNAs. Differential miRNA profiles were analyzed using the miRNA qRT-PCR-based assay. Two of the most upregulated miRNAs were selected and validated. The miR-196a/-196b levels were significantly increased in gastric cancer (GC) tissues (n = 109). Overexpression of miR-196a/-196b was significantly associated with tumor progression and poorer 5-year survival outcomes. Overexpression of miR-196a/-196b enhances GC cell migration and invasion. Further, radixin was identified as a target gene of miR-196a/-196b. Elevated miR-196a/-196b expression in GC cells led to reduced radixin protein levels and vice versa. Notably, an inverse correlation between miR-196a/-196b and radixin mRNA and protein expression was observed in GC tissues with in situ hybridization and immunohistochemistry analyses. Together, miR-196a/-196b inhibitory oligonucleotides or overexpression of the radixin may thus have therapeutic potential in suppressing GC metastasis.
Keywords :
Prognosis , Gastric cancer , metastasis , miR-196a/-196b , radixin
Journal title :
Cancer Letters
Serial Year :
2014
Journal title :
Cancer Letters
Record number :
1824835
Link To Document :
بازگشت