Title of article
Enriched CD44+/CD24− population drives the aggressive phenotypes presented in triple-negative breast cancer (TNBC)
Author/Authors
Ma، نويسنده , , Fei and Li، نويسنده , , Huihui and Wang، نويسنده , , Haijuan and Shi، نويسنده , , Xiuqing and Fan، نويسنده , , Ying and Ding، نويسنده , , Xiaoyan and Lin، نويسنده , , Chen and Zhan، نويسنده , , Qimin and Qian، نويسنده , , Haili and Xu، نويسنده , , Binghe، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
7
From page
153
To page
159
Abstract
The mechanism underlying the aggressive behaviors of triple negative breast cancer (TNBC) is not well characterized yet. The association between cancer stem cell (CSC) population and the aggressive behaviors of TNBC has not been established. We found the CD44+/CD24− cell population was enriched in TNBC tissues and cell lines, with a higher capacity of proliferation, migration, invasion and tumorigenicity as well as lower adhesion ability. The CD44+/CD24− cell population with cancer stem cell-like properties may play an important role in the aggressive behaviors of TNBC. This discovery may lead to new therapeutic strategies targeting CD44+/CD24− cell population in TNBC.
Keywords
Triple negative breast cancer , CD44+/CD24?. , Cancer stem cells
Journal title
Cancer Letters
Serial Year
2014
Journal title
Cancer Letters
Record number
1825030
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