Title of article
β6 integrin induces the expression of metalloproteinase-3 and metalloproteinase-9 in colon cancer cells via ERK-ETS1 pathway
Author/Authors
Gao، نويسنده , , Huijie and Peng، نويسنده , , Cheng and Liang، نويسنده , , Benjia and Shahbaz، نويسنده , , Muhammad and Liu، نويسنده , , Song and Wang، نويسنده , , Ben-hui Sun، نويسنده , , Qi and Niu، نويسنده , , Zhengchuan and Niu، نويسنده , , Weibo and Liu، نويسنده , , Enyu and Wang، نويسنده , , Jiayong and Lin، نويسنده , , Pengfei and Wang، نويسنده , , Jian-Jin Niu، نويسنده , , Jun، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
11
From page
427
To page
437
Abstract
We previously reported that β6 integrin played an important role in the progression of colon cancer. In this study, we demonstrated that β6 integrin induced the expression of MMP-3/MMP-9 and the invasion of colon cancer cells. Moreover, that function was abolished by the inhibition of ERK/MAPK pathways or knockdown of ETS1, an important transcription factor of MMP genes. Here, we showed that β6 induced phosphorylation of ETS1 via the ERK/MAPK pathways, through which the MMP-3/MMP-9 promoters were stimulated, thereby leading to the up-regulation of MMP-3/MMP-9, and subsequent the invasion of colon cancer cells.
Keywords
Colon cancer , ETS1 , ?6 integrin
Journal title
Cancer Letters
Serial Year
2014
Journal title
Cancer Letters
Record number
1825281
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