Title of article :
Cytogenetic findings in familial B-cell chronic lymphocytic leukemia: a report of two cases in a family
Author/Authors :
Espinet، نويسنده , , Blanca and Salido، نويسنده , , Marta and Hernلndez، نويسنده , , José ءngel and Zamora، نويسنده , , Lurdes and Bosch، نويسنده , , M.Alba and Serrano، نويسنده , , Sergi and Solé، نويسنده , , Francesc، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
Familial B-cell chronic lymphocytic (B-CLL) leukemia has been defined as an entity epidemiologically different from sporadic B-CLL. Cytogenetic abnormalities in familial B-CLL, studied either by conventional cytogenetics or by interphase fluorescence in situ hybridization (i-FISH), have rarely been reported. We report a two-case family affected with B-CLL showing two different abnormal karyotypes detected by conventional cytogenetics [46,XX,del(7)(q32) and 46,XY,add(1)(p36),del(6)(q21)] but sharing a del(13)(q14) at the D13S319 locus, detected by interphase fluorescence in situ hybridization.
Journal title :
Cancer Genetics and Cytogenetics
Journal title :
Cancer Genetics and Cytogenetics