Title of article :
Cryptic deletion involving the ATM locus at 11q22.3∼q23.1 in B-cell chronic lymphocytic leukemia and related disorders
Author/Authors :
Virginie Eclache-Saudreau، نويسنده , , Virginie and Caulet-Maugendre، نويسنده , , Sylvie and Poirel، نويسنده , , Hélène A. and Djemai، نويسنده , , Mohand and Robert، نويسنده , , Jacqueline and Lejeune، نويسنده , , Françoise and Raphaël، نويسنده , , Martine، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
5
From page :
72
To page :
76
Abstract :
B-cell chronic lymphocytic leukemia (B-CLL) follows a heterogeneous clinical course, and several biological parameters have been investigated to try to predict its clinical outcome. New staging systems including cytogenetics and CD38 expression as predictive values have been developed. Deletions of 11q22.3∼q23.1 detected at diagnosis in cases of CLL patients have been associated with a relatively aggressive disease. This region, which contains the ataxia telangiectasia mutated (ATM) locus, may be implicated in the pathogenesis of lymphoid malignancies. We developed a set of dual-color specific probes to evaluate the ATM deletion by means of fluorescence in situ hybridization (FISH). We also used flow cytometry to investigate CD38 expression. Forty-one patients with CLL or low-grade B-cell lymphomas were studied at diagnosis or before treatment. FISH showed that only three CLL patients had deletions in the 11q23 locus; all three had progressive disease and were resistant to treatment. These data show that our FISH set of probes efficiently detects ATM deletions in CLL. No correlation was found between ATM deletions and CD38 expression level. These results confirm the prognostic significance of ATM deletions in CLL.
Journal title :
Cancer Genetics and Cytogenetics
Serial Year :
2004
Journal title :
Cancer Genetics and Cytogenetics
Record number :
1826025
Link To Document :
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