Title of article
A t(1;9)(q23.3∼q25;q34) affecting the ABL1 gene in a biphenotypic leukemia
Author/Authors
Ram?n Gonz?lez Garc??a، نويسنده , , Juan and Bohlander، نويسنده , , Stefan K. and Gutiérrez Angulo، نويسنده , , Melva and Amparo Esparza Flores، نويسنده , , Mar??a and Judith Picos C?rdenas، نويسنده , , Ver?nica and Pablo Meza Espinoza، نويسنده , , Juan and de la Luz Ayala Madrigal، نويسنده , , Mar??a and Rivera، نويسنده , , Horacio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
81
To page
83
Abstract
Recurring chromosome translocations, which are found in leukemia, can result in the inappropriate expression of oncogenes or in the formation of chimeric genes that code for structurally and functionally abnormal proteins. The chromosomal t(1;9)(q23.3∼q25;q34) was found in a patient with biphenotypic leukemia. Fluorescence in situ hybridization (FISH) analysis revealed that the break on chromosome 9 occurred in the ABL1 gene. The breakpoint on chromosome 1 occurred distal to the PBX1 gene at 1q23.3, as shown by FISH using BAC RP11-503N16 and RP11-403P14, which flank the PBX1 locus; hence, the ABL1 gene can be fused with another gene distal to PBX1 gene.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
2004
Journal title
Cancer Genetics and Cytogenetics
Record number
1826033
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