Title of article
MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity
Author/Authors
Morerio، نويسنده , , Cristina and Rapella، نويسنده , , Annamaria and Rosanda، نويسنده , , Cristina and Lanino، نويسنده , , Edoardo and Lo Nigro، نويسنده , , Luca and Di Cataldo، نويسنده , , Andrea and Maserati، نويسنده , , Emanuela and Pasquali، نويسنده , , Francesco and Panarello، نويسنده , , Claudio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
108
To page
112
Abstract
Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French–American–British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneity.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
2004
Journal title
Cancer Genetics and Cytogenetics
Record number
1826050
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