Author/Authors :
Chang، نويسنده , , Hong and Sutherland، نويسنده , , Rob and Nayar، نويسنده , , Rakash and Li، نويسنده , , Dan and Kamel-Reid، نويسنده , , Suzane and Mile، نويسنده , , Mary-Anne and Messner، نويسنده , , Hans and Lipton، نويسنده , , Jeff، نويسنده ,
Abstract :
We report the case of a 57-year-old man who developed chronic lymphocytic leukemia (CLL) several months after the initial diagnosis of Philadelphia (Ph) chromosome–positive (Ph+) chronic myelocytic leukemia. CLL cells were purified by using fluorescence-activated cell sorting and further analyzed using interphase fluorescence in situ hybridization with probes to detect the BCR/ABL fusion gene. We provide evidence that the CLL cells arose in a Ph− clone.
