Author/Authors :
Costa، نويسنده , , Sandra Camargo Pinto Ferraz Fabbri and Wanderley Lopes de Souza ، نويسنده , , Daniela and Pereira، نويسنده , , Deolinda and Vasconcelos، نويسنده , , André and Afonso-Lopes، نويسنده , , Carlos and Osَrio، نويسنده , , Teresa and Lopes، نويسنده , , Carlos and Medeiros، نويسنده , , Rui، نويسنده ,
Abstract :
The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case–control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (OR=2.46 95% CI 1.20–5.06; P=0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (OR=3.40 95% CI 1.61–7.15; P=0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer.
Keywords :
Ovarian cancer , polymorphisms , XPD , NER , DNA repair
