A novel t(X;2)(q13;q35) in clear cell sugar tumor of bone

Reciprocal translocations have been identified in a number of solid tumors and can serve as both diagnostic and prognostic indicators. When these translocations occur as the primary or sole chromosome aberration, they can potentially be associated with the formation of tumor-specific fusion genes at the translocation breakpoints. We present what is to our knowledge the first reported case of a primary clear cell sugar tumor of bone displaying a novel t(X;2)(q13;q35) as the sole cytogenetic aberration.