Author/Authors :
Bharath Boregowda، نويسنده , , Rajeev K. and Olabisi، نويسنده , , Oyenike O. and Abushahba، نويسنده , , Walid and Jeong، نويسنده , , Byeong-Seon and Haenssen، نويسنده , , Keneshia K. and Chen، نويسنده , , Wenjin and Chekmareva، نويسنده , , Marina and Lasfar، نويسنده , , Ahmed and Foran، نويسنده , , David J. and Goydos، نويسنده , , James S. and Cohen-Solal، نويسنده , , Karine A.، نويسنده ,
Abstract :
In the present study, we investigated the role of the transcription factor RUNX2 in melanomagenesis. We demonstrated that the expression of transcriptionally active RUNX2 was increased in melanoma cell lines as compared with human melanocytes. Using a melanoma tissue microarray, we showed that RUNX2 levels were higher in melanoma cells as compared with nevic melanocytes. RUNX2 knockdown in melanoma cell lines significantly decreased Focal Adhesion Kinase expression, and inhibited their cell growth, migration and invasion ability. Finally, the pro-hormone cholecalciferol reduced RUNX2 transcriptional activity and decreased migration of melanoma cells, further suggesting a role of RUNX2 in melanoma cell migration.
Keywords :
Transcription factor , melanoma , FAK , MIGRATION , Cholecalciferol (Vitamin D3) , RUNX2
