Title of article
RUNX2 is overexpressed in melanoma cells and mediates their migration and invasion
Author/Authors
Bharath Boregowda، نويسنده , , Rajeev K. and Olabisi، نويسنده , , Oyenike O. and Abushahba، نويسنده , , Walid and Jeong، نويسنده , , Byeong-Seon and Haenssen، نويسنده , , Keneshia K. and Chen، نويسنده , , Wenjin and Chekmareva، نويسنده , , Marina and Lasfar، نويسنده , , Ahmed and Foran، نويسنده , , David J. and Goydos، نويسنده , , James S. and Cohen-Solal، نويسنده , , Karine A.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
10
From page
61
To page
70
Abstract
In the present study, we investigated the role of the transcription factor RUNX2 in melanomagenesis. We demonstrated that the expression of transcriptionally active RUNX2 was increased in melanoma cell lines as compared with human melanocytes. Using a melanoma tissue microarray, we showed that RUNX2 levels were higher in melanoma cells as compared with nevic melanocytes. RUNX2 knockdown in melanoma cell lines significantly decreased Focal Adhesion Kinase expression, and inhibited their cell growth, migration and invasion ability. Finally, the pro-hormone cholecalciferol reduced RUNX2 transcriptional activity and decreased migration of melanoma cells, further suggesting a role of RUNX2 in melanoma cell migration.
Keywords
Transcription factor , melanoma , FAK , MIGRATION , Cholecalciferol (Vitamin D3) , RUNX2
Journal title
Cancer Letters
Serial Year
2014
Journal title
Cancer Letters
Record number
1826383
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