Title of article
Genotoxicity and sister chromatid exchange in patients with myelodysplastic disorders
Author/Authors
?ztürk، نويسنده , , ?ükrü and Palanduz، نويسنده , , ?ükrü and Cefle، نويسنده , , K?vanç and Tutkan، نويسنده , , Gülçin and Uçur، نويسنده , , Ali and Dinçol، نويسنده , , Günça? and Nalçac?، نويسنده , , Meliha and Aktan، نويسنده , , Melih and Yavuz، نويسنده , , Selim and Küçükkaya، نويسنده , , Reyhan Diz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
148
To page
150
Abstract
In this study, we aimed to evaluate genotoxicity by sister chromatid exchange frequency in the peripheral lymphocytes of patients with myelodysplastic syndrome (MDS). The study population consisted of 16 patients (females/males:6/10; mean age: 61.68 ± 13.08 years) diagnosed with “refractory anemia” according to FAB classification. The results were compared with an age- and sex-matched control group. The sister chromatid exchange frequency in the study group was found to be significantly higher than the control group (8.3 ± 11 vs. 6.83 ± 1.07, P = 0.0046). We suggest that increased DNA damage, which is revealed by the increased sister chromatid exchange in the present study may play a role in the etiopathogenesis of MDS.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
2005
Journal title
Cancer Genetics and Cytogenetics
Record number
1826751
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