Author/Authors :
Tirado، نويسنده , , Carlos A. and Jahn، نويسنده , , Jennifer A. and Scheerle، نويسنده , , Jay and Eid، نويسنده , , Maya and Meister، نويسنده , , Robert J. and Christie، نويسنده , , Robert J. and Croft، نويسنده , , Calvin D. and Wallingford، نويسنده , , Steven and Heritage، نويسنده , , Deborah W. and Mowrey، نويسنده , , Philip N. and Meloni-Ehrig، نويسنده , , Aurelia M.، نويسنده ,
Abstract :
Fluorescence in situ hybridization (FISH) analysis of the bone marrow of a 24-year-old man diagnosed with acute promyelocytic leukemia (APL) revealed a variant pattern with one fusion signal instead of the typical two fusions expected with the probe set used. The combined FISH and conventional chromosome analyses suggested that two subsequent translocations had occurred in this patient involving the same chromosomes 15 and 17. As the prognostic outcome in APL is strictly associated with the presence of a PML/RARA fusion, it is useful and necessary to perform both cytogenetic and FISH analyses of a variant t(15;17) to determine the status of the PML/RARA fusion.
