Author/Authors :
Meloni-Ehrig، نويسنده , , Aurelia M. and Tirado، نويسنده , , Carlos A. and Chen، نويسنده , , Kuoping and Jahn، نويسنده , , Jennifer and Suchan، نويسنده , , Stephany and Scheerle، نويسنده , , Jay and Crosby، نويسنده , , Maria Gabriela and Meany، نويسنده , , Holly and Seibel، نويسنده , , Nita and Leitenberg، نويسنده , , David and Heritage، نويسنده , , Deborah W. and Mowrey، نويسنده , , Philip N.، نويسنده ,
Abstract :
We present a case of del(14)(q21) as a sole abnormality in a 4-year-old boy diagnosed with precursor B-cell acute lymphoblastic leukemia (pre-B ALL). To our knowledge, this is the first case of isolated del(14)(q21) in pre-B ALL. Two pretreatment bone marrow samples obtained 5 days apart were analyzed by cytogenetics. The G-banded karyotypes of the two samples were similar, differing only in the ratio of normal/abnormal metaphases detected. Both samples showed a del(14)(q21) as the only abnormality. Fluorescence in situ hybridization performed using the probes TEL/AML1 and immunoglobulin heavy chain (IGH) showed no fusion involving the TEL and AML1 genes and only a single IGH signal in 20% of the interphase cells analyzed.
