Title of article
Brain metabolite changes in alcoholism: An in vivo proton magnetic resonance spectroscopy (MRS) study
Author/Authors
Jagannathan، نويسنده , , N.R. and Desai، نويسنده , , N.G. and Raghunathan، نويسنده , , P.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
5
From page
553
To page
557
Abstract
Image-guided, single voxel, localized proton magnetic resonance (MR) spectroscopy was performed to assess the brain metabolite changes in 10 (n = 10) alcoholic patients in the frontal lobe, cerebellum, and thalamus regions. The spectra obtained were characterized by a reduced N-acetyl-aspartate (NAA) to choline (Cho) (p < .01) and NAA to total creatine (Cr + PCr) (p < .01) ratios relative to age-matched (n = 27) controls. These decreased ratios correspond to depleted concentration of the metabolite levels such as NAA and Cho. Reduction of NAA is consistent with the neuronal loss while reduction in Cho suggests significant changes in the membrane lipids of alcoholics.
Keywords
Alcoholism , Brain metabolite changes , NAACho , NAA(Cr + PCr) , magnetic resonance spectroscopy (MRS)
Journal title
Magnetic Resonance Imaging
Serial Year
1996
Journal title
Magnetic Resonance Imaging
Record number
1827314
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