Title of article
A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1)
Author/Authors
Todori?-Zivanovi?، نويسنده , , Biljana and Marisavljevi?، نويسنده , , Dragomir and Surace، نويسنده , , Cecilia and ?emeriki?، نويسنده , , Vesna and Markovi?، نويسنده , , Olivera and Krtolica، نويسنده , , Koviljka and Tatomirovi?، نويسنده , , ?eljka and Cikota، نويسنده , , Bojana and Magi?، نويسنده , , Zvonko and Rocchi، نويسنده , , Mariano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
180
To page
185
Abstract
Chronic myeloid leukemia (CML) is a clonal malignant disorder of a pluripotent hematopoetic stem cell characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients. Cryptic or “masked” BCR/ABL gene rearrangements may be found in cases with a normal karyotype and in cases with the complex karyotype, in which typical t(9;22) is not visible at the microscopic level. Those rearrangements can now be detected by fluorescence in situ hybridization. Here, we report on a novel and complex Ph chromosome-negative CML case with a t(6;9)(p21;q34.1) in which the BCR/ABL fusion gene is located at 6p21.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
2006
Journal title
Cancer Genetics and Cytogenetics
Record number
1827552
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