Author/Authors :
HADHRI، RIM نويسنده Department of pathology, Fattouma Bourguiba Hospital, Monastir, Tunisia , , HAMMEDI، FATEN نويسنده Department of pathology, Fattouma Bourguiba Hospital, Monastir, Tunisia , , Binous، Yassine نويسنده Department of Urology, Tahar-Sfar Hospital, 5000 Monastir, Tunisia , , MOUSSA، ADNENE نويسنده Department of pathology, Fattouma Bourguiba Hospital, Monastir, Tunisia , , NJIM، Leila نويسنده Department of pathology.FattoumaBourguiba Hospital, Monastir, Tunisia , , Zakhama، Abdefatteh نويسنده Department of Pathology, Fattouma Bourguiba Hospital, Tahar-Sfar Hospital, 5000 Monastir, Tunisia Zakhama, Abdefatteh
Abstract :
Primary renal synovial sarcoma is a rare tumor, with a poor prognosis which must be differentiated from other
renal tumors. We report a new case of renal synovial sarcoma in a 60 year-old man. Histologic examination
showed a proliferation of monomorphic spindle cells arranged in fascicles with hemangiopericytomatous pattern.
Tumor cells were immunoreactive for bcl2, CD99, cytokeratin and epithelial membrane antigen. The diagnosis of
spindle cell type monophasic synovial sarcoma was proposed and confirmed by fluorescence in situ hybridization.
Patient was treated with chemotherapy. He developed bone and liver metastasis and died 7 months after nephrectomy.
The diagnosis of renal synovial sarcoma is based on histological and immunohistochemical studies and must
be confirmed by molecular techniques which showed the translocation t (X; 18).
