Title of article :
Unusual type of TLS/FUS-ERG chimeric transcript in a pediatric acute myelocytic leukemia with 47,XX,+10,t(16;21)(p11;q22)
Author/Authors :
Choi، نويسنده , , Hyun-Woo and Shin، نويسنده , , Myung-Geun and Sawyer، نويسنده , , Jeffrey R. and Cho، نويسنده , , Duck and Kee، نويسنده , , Seung-Jung and Baek، نويسنده , , Hee-Jo and Kook، نويسنده , , Hoon and Kim، نويسنده , , Hyeoung-Joon and Shin، نويسنده , , Jong-Hee and Suh، نويسنده , , Soon-Pal and Hwang، نويسنده , , Tai-Ju and Ryang، نويسنده , , Dong-Wook، نويسنده ,
Abstract :
We report on a case of pediatric acute myelocytic leukemia showing 47,XX,+10,t(16;21)(p11;q22) that resulted in an unusual TLS/FUS-ERG chimeric transcript. The leukemic cells showed erythrophagocytosis, positive reactions for myeloperoxidase and Sudan black B stains, and negative reactions for periodic acid–Schiff and α-naphtyl butyrate esterase stains as well as expression of myeloid antigens. We also confirmed a very rare type of TLS/FUS-ERG chimeric transcript by fusion of the 5′ part of the TLS/FUS gene in chromosome 16p11 and the 3′ part of the ERG gene in chromosome 21q22 using reverse-transcriptase polymerase chain reaction and direct sequencing. After achieving a complete remission with two cycles of induction chemotherapy, the patient received an umbilical cord blood transplantation.
