Author/Authors :
Stasevich، نويسنده , , Irina and Utskevich، نويسنده , , Regina and Kustanovich، نويسنده , , Anatoly and Litvinko، نويسنده , , Natallia and Savitskaya، نويسنده , , Tatsiana and Chernyavskaya، نويسنده , , Svetlana and Saharova، نويسنده , , Olga and Aleinikova، نويسنده , , Olga، نويسنده ,
Abstract :
Using both conventional and molecular cytogenetic methods, we found five new cases of t(10;11)(p12;q23). This translocation represented 28% of all cases of childhood AML treated at our center in 2004, and 63% of AML with rearrangements of 11q23. We describe three mechanisms for the translocation. Different fragments of 11q were involved in four of the five cases. One patient showed a cytogenetically cryptic insertion of 5′ part of MLL into the 3′ part of MLLT10 in 10p12. The median event-free survival of patients was 8.1 months, and we conclude that the t(10;11)(p12;q23) is associated with unfavorable prognosis in childhood acute myeloid leukemia.
