Author/Authors :
Rowe، نويسنده , , Leslie R. and Brothman، نويسنده , , Arthur R. and Nibley، نويسنده , , William E. and Gaffney، نويسنده , , Michael R. and Chen، نويسنده , , Zhong، نويسنده ,
Abstract :
Secondary chromosomal changes are known to develop in Philadelphia chromosome-negative (Ph−) cells of chronic myelogenous leukemia (CML) patients after treatment with imatinib mesylate, an ABL kinase inhibitor. We report here a novel case of a pericentric inversion of chromosome 16 as the sole cytogenetic abnormality in Ph− cells after treatment of Ph+ CML with imatinib.
