Author/Authors :
Etienne، نويسنده , , Anne and Carbuccia، نويسنده , , Nadine and Adélaïde، نويسنده , , José and Bekhouche، نويسنده , , Ismahane and Rémy، نويسنده , , Virginie and Sohn، نويسنده , , Claudine and Sainty، نويسنده , , Danielle and Gastaut، نويسنده , , Jean-Albert and Olschwang، نويسنده , , Sylviane and Birnbaum، نويسنده , , Daniel and Mozziconacci، نويسنده , , Marie-Joëlle and Chaffanet، نويسنده , , M، نويسنده ,
Abstract :
We report two cases of translocation associated with deletion on derivative chromosomes in atypical myeloproliferative disorder (MPD). In a MPD with t(3;12)(q29;q14), the rearrangement targeted the HMGA2 locus at 12q14 and deleted a region of about 1.5 megabases (Mb) at 3q29. In an MPD with t(9;12)(q13∼q21;q22) and JAK2 V617F mutation, array comparative genomic hybridization delineated a deletion of about 3 Mb at 9q13∼q21 and a deletion of about 2 Mb at 12q22 containing SOCS2. These results show that close examination of translocations in hematopoietic diseases may reveal associated microdeletions. The role of these deletions is discussed.
