Premature chromatid separation in a woman with carcinoma in situ of the uterine cervix and in her son with keratoacanthoma

An increased frequency of cells with premature chromatid separation (PCS) involving most chromosomes of a metaphase was observed in blood cultures of both a woman and her son with tumor. The mother had carcinoma in situ of the cervix, diagnosed at age of 42 years, and her son had keratoacanthoma, diagnosed at age of 23 years. To our knowledge, these are the first reported cases of carcinoma in situ of the uterine cervix and keratoacanthoma in patients with PCS. These findings provide additional evidence for a possible association of PCS and predisposition to malignancies.