Author/Authors :
Costa Raiol، نويسنده , , Lلuren Clلudia and Figueira Silva، نويسنده , , Evely Cristina and Mendes da Fonseca، نويسنده , , Diana and Leal، نويسنده , , Mariana Ferreira and Guimarمes، نويسنده , , Adriana Costa and Calcagno، نويسنده , , Danielle Queiroz and Khayat، نويسنده , , André Salim and Assumpçمo، نويسنده , , Paulo Pimentel and de Arruda Cardoso-Smith، نويسنده ,
Abstract :
Gastric cancer is the second leading cause of death by cancer in Brazil. Early gastric cancer represents ∼10% of gastric cancer cases in some services of Brazil, which underscores the need for early gastric cancer diagnosis that could lead to better prognosis. There are few published studies of cytogenetic alterations in early gastric cancer. To evaluate MYC copy number and its protein expression, we performed fluorescence in situ hybridization and immunohistochemical analyses in five early gastric adenocarcinomas in individuals from northern Brazil. Three signals of MYC and MYC immunoreactivity were observed in all five samples, regardless of histologic type, tumor extension, or lymph nodal status. These novel findings concerning MYC copy number alteration in early gastric cancer suggest that MYC alteration is observed in the beginning of gastric carcinogenesis and could be used as a therapeutic target.
