Author/Authors :
Rosati، نويسنده , , Roberto and Cerrato، نويسنده , , Flavia and Doghman، نويسنده , , Mabrouka and Pianovski، نويسنده , , Mara A.D. and Parise، نويسنده , , Guilherme A. and Custَdio، نويسنده , , Gislaine and Zambetti، نويسنده , , Gerard P. and Ribeiro، نويسنده , , Raul C. and Riccio، نويسنده , , Andrea G.P.R. Figueiredo، نويسنده , , Bonald C. and Lalli، نويسنده , , Enzo، نويسنده ,
Abstract :
A germline TP53 R337H mutation is present in childhood adrenocortical tumors (ACT) from southern Brazil. Other genetic alterations are also frequently found in these tumors. This study was designed to assess whether alterations of the 11p15 region exist in childhood ACT, accounting for IGF2 overexpression in these tumors, and how they are related to clinical outcome. Tumor DNA of 12 children with ACT (4 adenomas and 8 carcinomas) and from the blood of their parents was analyzed. All patients showed 11p15 loss of heterozygosity (LOH) in the tumor. In contrast to the single case of paternal LOH, IGF2 was overexpressed in tumors with maternal allele loss. Our data show that 11p15 LOH is a widespread finding in childhood ACT not related with malignancy, contrary to adult ACT. Alterations in the expression of other genes in the same region (e.g., CDKN1C) may contribute to ACT tumorigenesis. ©2008 Elsevier Inc. All rights reserved.
