Author/Authors :
de Figueiredo، نويسنده , , Amanda Faria and Mkrtchyan، نويسنده , , Hasmik and Liehr، نويسنده , , Thomas and Soares Ventura، نويسنده , , Eliane Maria and de Jesus Marques-Salles، نويسنده , , Terezinha and Santos، نويسنده , , Neide and Ribeiro، نويسنده , , Raul Corrêa and Abdelhay، نويسنده , , Eliana and Macedo Silva، نويسنده , , Maria Luiza، نويسنده ,
Abstract :
Hyperdiploidy is rarely observed in childhood acute myeloid leukemia (AML). Described here is the case of a 2½-year-old girl with AML-M5 and 51 chromosomes characterized by double tetrasomy of chromosomes 8 and 21 and also a neocentric derivative chromosome neo(1)(qter→q23∼24::q23∼24→q43→neo→q43→qter). Little is known about the prognostic significance of these chromosomal abnormalities in childhood AML. In the actual case, complete remission was achieved after chemotherapy, which continued for 7 months. No acquired neocentric chromosome 1 has been described previously, even though neocentromere formation has been reported for other chromosomes in neoplasms.
